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However,in a p53-null background homozygous mice survive and the expression of MDM2-Aalters the tumor spectrum of transgenic p53-null mice toward increased T-cell lym-phomagenesis [44]. The Evaluation Items help identify those topics that should beconsidered in arriving at the rating. The final set of SNPs was thenanalysed using the combined screening and replication datasets, because thisshould produce the most reliable effect sizes and smallest p-values (Table 9.8).Unlike examples covered in Chapters 5–7, in which there is a pre-definedexposure, and so the p-value often just needs to be <0.05, conclusions on SNPsare only made using the smallest p-values, for example, 3.0?10?8# for the SNPrs12722489 (and gene IL2RA)

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